NOSTRUM BIODISCOVERY

RETHINK & ACCELERATE

supercomputing power

DRUGDISCOVERY

highlights

ASTRAZENECA ACCELERATES PAR2 USING PELE

AstraZeneca in collaboration with Heptares Therapeutic, has made significant progress with the new target called PAR2, using the PELE simulation software, as reported in Nature. PAR2 has applications for the generation of new drugs in the inflammatory pain field.

More Info

NBD JOINS BARCELONA BIOINFORMATICS (BIB)

NBD joins Barcelona Bioinformatics (BIB), established to meet the need for generating synergies between biology and computer science, for a stronger union between these areas, and for the development of high-quality education and training programmes in the creation of bioinformatic talent.

More Info

NBD GETS FUNDED BY CDTI

NBD has obtained a NEOTEC grant, one of the top-tier funding programmes focussed on highly innovative SMEs.

More Info

NBD JOINS CATALONIABIO

NBD has recently joined CataloniaBio, the catalan association formed by biotech and pharmaceutical companies.

More Info

PELE RANKED AS TOP TIER IN THE 2014 CSAR

PELE ranked as top tier in the 2014 Community Structure Activity Resource blind test, set up by U.Michigan with unpublished data from GSK.

More Info

NBD SOON TO HAVE ONE OF THE BEST PPD CODES

NBD soon to have one of the highest-ranked protein-protein docking programs as determined in the Critical Assessment of Prediction of Interactions (CAPRI)

More Info

IMPROVING CURRENT NUCLEIC ACID FORCE-FIELDS

NBD’s Chairman, Modesto Orozco has recently led a coordinated effort to improve current nucleic acid force-fields.

MORE INFO

PELE FEATURED AS A TIER-1 TOOL BY ASTRAZENECA

AstraZeneca positioning PELE as a tool applicable for rapid drug design cycles for binding mode and induced fit prediction.

More Info

ABOUT US

NBD | Nostrum Biodiscovery is a young enterprise created in 2015 which aims to collaborate with pharmaceutical and biotech companies dedicated to the development of drugs and molecules of biotechnological interest. The main focus of NBD is based on helping these companies to maximize the success of their drug discovery and development process and consequently, increasing their market success.

The fact is that R+D policies are experimenting a significant paradigm change. Basically, the pharmaceutical industry has changed its discovery in-house model into a partially outsourced risk system. Thus, the companies not only are reducing their costs but they can also expand their strategies regarding risk distribution and technological expansion, especially in terms of the quality and diversity of their innovation.

NOSTRUM BIODISCOVERY

NBD advantages are its technologies, allowing the saving of costs and the acceleration of the whole process. Secondly, the level of calculation and prediction capacity by computation, which directly impacts research reliability. Lastly, the team experience and the research excellence which has been strongly demonstrated by the internationally-recognized institutions that support this project for years now.

Rethink Drug Development
%
High-performance Computing
%
Accelerate Drug Pipeline
%
Redesign and Rationalize Discovery
%
Download Fact Sheet

Company Overview

 

 

Services

RATIONAL SMALL MOLECULE DESIGN

NBD is involved in the application of computational chemistry tools aimed at accelerating, streamlining and optimizing the design of small molecules in early discovery. In order to perform most of rational small molecule design NBD is endowed, among a series of different softwares, with one of the most highly regarded platforms in the industry, the Schrodinger suite of programs.

NBD scientists have the experience and tools needed to handle cheminformatics problems such as small molecule library management, chemical space and diversity analysis, in silico combinatorial library construction, drug-likeness and in silico safety profiling.
NBD scientists have all tools needed to implement a ligand-based approach to the design of new small molecules with biological activity, from 2D similarity to 3D molecular alignment and shape and pharmacophore-based perception and screening.
NBD have ample experience in structure-based methods applied in drug discovery projectsboth from an academic and an industrial perspective. NBD is endowed with all tools needed to implement a structure-based approach to the design of new small molecules with biological activity, from target druggability and flexibility assessment, to docking, in silico fragment screening, molecular dynamics and homology modeling.
Download RATIONAL SMALL MOLECULE DESIGN

OMICS-BASED DISCOVERY

NBD is involved in the application of bioinformatics and simulation tools aimed at unveiling the genetic basis of disease, the pathological changes associated to mutations, the genetic variation among different sub-populations and their relationships with disease risk, patient stratification and response to therapy. The deluge of omics-based data is progressively being incorporated earlier in discovery and development projects.

NBD scientists have a wide experience in the macromolecular simulation field, having been engaged for decades in in silico studies of structure and flexibility of DNA, RNA and chemically modified nucleic acids, where a great effort has been devoted to the development and improvement of currently available force fields. They have also been involved in different projects of enzyme engineering, where not only the affinity but also the kinetics of binding plays a crucial role.
NBD scientists have been involved in many national and international genomics initiatives, such as the sequencing of the tomato genome, genome-wide studies of mutations associated to chronic lymphocytic leukemia, the development of in silico tools for the annotation of mutations in cancer, genome-wide prediction of promoter regions, epigenetics processes associated to the packaging of DNA in nucleosomes and others.

Download OMICS-BASED DISCOVERY

 

Proprietary Technologies

The company will use cutting-edge technologies, and one of its business lines will involve supporting the development of drugs for precision medicine.
PELE Simulation

Software for predicting the dynamic interactions between proteins and ligands.

+ More info PELE

ED/MD Simulation

Method to explore the flexibility of macromolecular targets and their use in rational drug design.

+ More info ED/MD

MDWeb

Suite of programmes that facilitates rapid workflows to automate molecular dynamics calculations.

+ More info MDWeb

MoDEL

A database that holds simulations of more than 1700 proteins. This is the second-largest database of this nature worldwide.

+ More info MoDEL

ChemistriX

Virtual compound library built with synthetic chemical knowledge with the purpose of complementing the chemistry available in current catalogues.

+ More info ChemistriX

Third-party Technologies

In order to perform most of rational small molecule design tasks NBD is endowed, among a series of different softwares, with one of the most highly regarded platforms in the industry, the Schrodinger suite of programmes.

"Things are as they are because they were as they were."

- Thomas Gold -

"The good thing about science is that it’s true whether or not you believe in it."

- Neil deGrasse Tyson -

"The secret of business is to know something that nobody else knows. "

- Aristotle Onassis -

Our Partners and Collaborators

Nostrum BioDiscovery boasts leading bioinformatic technologies developed by researchers Modesto Orozco and Victor Guallar and their respective teams at the Institute for Research in Biomedicine (IRB) in Barcelona and the Barcelona Supercomputing Center - National Supercomputing Center (BSC -CNS), with support from the Bosch i Gimpera Foundation at the University of Barcelona and the Catalan Institute for Research and Advanced Studies (ICREA).

The quality of the research performed by Drs. Orozco and Guallar has been recognised through the award of an ERC Advanced Grant each—the most prestigious research distinction in the European Union. Furthermore, in 2007 and 2012 they received support from the Technology Transfer Programme run by the Botín Foundation, which provides funding and HR support to allow companies to get their early-stage products and biotech services into the market.

 

 

 

Contact US

Address

Calle Jordi Girona 29, Edificio Nexus II Despacho D128 Barcelona, CP.08034 Spain

Can we help you? Phone: (+34) 679 894 076

Categories

+ Biotech

+ Supercomputing

+ Drug Discovery

+ Rethink and Accelerate

Copyrights © 2017 All Rights Reserved by NBD I Nostrum Biodiscovery