PM I Project Manager
Joan Coines graduated in Biochemistry at University of Barcelona (UB) in 2014 and obtained a master's degree in Bioengineering at Chemical Institute of Sarrià (IQS) in 2016. Since then, he has been investigating enzymes by means of computational and theoretical chemistry methods during his PhD thesis at UB, which is about to complete. He is currently working at Nostrum Biodiscovery (NBD) as a Project Manager in the Enzyme Engineering division.
His research has been focused on the elucidation of reaction mechanisms in glycosidase catalysis, employing a multi-scale approach which involves molecular dynamics, hybrid methods (QM/MM) and metadynamics. Among his studies, the novel engineering of a hydrolytic glycosidase into a phosphorylase stands out. Additionally, he worked at the University of Cagliari analyzing the molecular transport across bacterial porins. He has published several scientific articles in peer-review journals such as J. Am. Chem. Soc, Chemistry–A European Journal, Phys. Chem. Chem. Phys and ChemComm.